The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease
复制标题
DOI：
10.1016/j.neulet.2007.09.023
复制
发表时间：
2007-11-12
影响因子：
2.5
通讯作者：
Lannfelt, Lars
中科院分区：
文献类型：
--
作者：
Giedraitis, Vilmantas;Sundelof, Johan;Lannfelt, Lars
具有40个（A β 40）和42个（A β 42）氨基酸的淀粉样蛋白-β（A β）是阿尔茨海默病（AD）脑中淀粉样蛋白斑块的主要组分，可以在人脑脊液（CSF）和血浆中测量。尽管AD患者的CSF A β 42降低，但一些研究报告了AD和轻度认知障碍（MCI）受试者的血浆A β水平变化。到目前为止，尚不清楚健康个体中CSF和血浆A β水平是否以及如何相互关联，尽管早期对AD患者的研究发现CSF和血浆A β之间没有相关性。我们测量了AD患者（n=39）、MCI患者（n=29）和健康对照受试者（n= 18）的配对CSF和血浆样本中的A β 40和A β 42。我们在健康个体中观察到A β 40和A β 42的CSF和血浆水平之间存在明显的相关性，而在AD或MCI病例中则没有这种相关性。与其他研究相似，我们也发现AD CSF中A β 42水平较低，而诊断组之间的血浆A β水平无显著差异。我们的研究结果表明，CSF和血浆A β之间的正常平衡可能会被破坏与淀粉样蛋白沉积在大脑中的启动。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Amyloid-beta (A beta) with 40 (A beta 40) and 42 (A beta 42) amino acids, the main components of amyloid plaques in the Alzheimer's disease (AD) brain, can be measured in human cerebrospinal fluid (CSF) and plasma. Whereas CSF A beta 42 is decreased in AD, some studies have reported changed plasma A beta levels in AD and in subjects with mild cognitive impairment (MCI). To this date it is unclear if and how CSF and plasma levels of A beta correlate with each other in healthy individuals, albeit earlier studies on AD patients found no correlation between CSF and plasma A beta. We have measured A beta 40 and A beta 42 in paired CSF and plasma samples from patients with AD (n=39), MCI (n=29) and healthy control subjects (n= 18). We observed a clear correlation between CSF and plasma levels for both A beta 40 and A beta 42 in healthy individuals, whereas no such correlation could be seen for AD or MCI cases. Similarly to other studies we also found low levels of A beta 42 in AD CSF, whereas there were no significant differences in plasma A beta levels between the diagnostic groups. Our findings suggest that the normal equilibrium between CSF and plasma A beta may be disrupted with the initiation of amyloid deposition in the brain. (c) 2007 Elsevier Ireland Ltd. All rights reserved.