Controlled release in transdermal pressure sensitive adhesives using organosilicate nanocomposites.
Controlled release in transdermal pressure sensitive adhesives using organosilicate nanocomposites.
复制标题
使用有机硅酸盐纳米复合材料控制透皮压敏粘合剂的释放。
DOI：
10.1007/s10439-007-9369-8
复制
发表时间：
2007
影响因子：
3.8
通讯作者：
Baskaran,Harihara
中科院分区：
文献类型：
--
作者：
Shaikh,Sohel;Birdi,Anil;Qutubuddin,Syed;Lakatosh,Eric;Baskaran,Harihara
采用溶液浇铸法制备了不同有机粘土含量的聚二甲基硅氧烷（PDMS）压敏胶。通过X射线衍射和原子力显微镜测定，在乙酸乙酯溶剂中，羟基封端的PDMS获得部分剥离的纳米复合材料。药物释放研究表明，初始突释大大减少，药物释放可以通过添加有机粘土控制。剪切强度和剪切粘合失效温度（SAFT）测量表明PSA纳米复合材料粘合剂的粘合性能显著改善。在较低的粘土加载量下，剪切强度显示出超过200%的改善，并且由于纳米分散的粘土片晶提供的增强，SAFT增加了约21%。已发现，通过优化有机硅酸盐添加剂在聚合物基质中的含量，可获得透皮PSA制剂对药物释放动力学的上级控制和粘合性能的同时改善。
Polydimethyl siloxane (PDMS) based pressure sensitive adhesives (PSA) incorporating organo-clays at different loadings were fabricated via solution casting. Partially exfoliated nanocomposites were obtained for the hydroxyl terminated PDMS in ethyl acetate solvent as determined by X-ray diffraction and atomic force microscopy. Drug release studies showed that the initial burst release was substantially reduced and the drug release could be controlled by the addition of organo-clay. Shear strength and shear adhesion failure temperature (SAFT) measurements indicated substantial improvement in adhesive properties of the PSA nanocomposite adhesives. Shear strength showed more than 200% improvement at the lower clay loadings and the SAFT increased by about 21% due to the reinforcement provided by the nano-dispersed clay platelets. It was found that by optimizing the level of the organosilicate additive to the polymer matrix, superior control over drug release kinetics and simultaneous improvements in adhesive properties could be attained for a transdermal PSA formulation.