Regression of early cholesterol-induced aortic lesions in rhesus monkeys.
Regression of early cholesterol-induced aortic lesions in rhesus monkeys.
复制标题
恒河猴早期胆固醇引起的主动脉病变的消退。
作者：
C. Tucker;C. Catsulis;J. Strong;D. Eggen
研究了恒河猴早期单纯由胆固醇诱发的主动脉病变的可逆性。使用了三组恒河猴：对照组喂食普通食物8周；进展组喂食致动脉粥样硬化饮食8周；消退组喂食致动脉粥样硬化饮食8周，然后再换回普通食物喂养16周。进展组动物产生的病变特征为在内皮细胞正下方有许多富含脂质的单核细胞，内膜平滑肌细胞中有大量脂滴，细胞外间隙有适量脂质。消退组动物的病变中含有的富含脂质的单核细胞较少，平滑肌细胞中的脂质减少，细胞外间隙中的脂质颗粒更大且数量更多。结果表明，喂食高胆固醇饮食8周后可预期地产生主动脉病变，并且在停止该饮食16周后病变发生质的变化。
The reversibility of early uncomplicated cholesterol-induced aortic lesions in rhesus monkeys was investigated. Three groups of Rhesus monkeys were used: the control group was fed a chow diet for 8 weeks; the progression group was fed an atherogenic diet for 8 weeks and the regression group was fed an atherogenic diet for 8 weeks and returned to the chow diet for 16 weeks. The lesions produced in the progression animals characteristically contained many lipid-laden monocytes immediately beneath the endothelium, abundant lipid droplets in intimal smooth muscle cells and moderate amounts of lipid in the extracellular spaces. Lesions in regression animals contained few lipid-laden monocytes, less lipid in smooth muscle cells and larger and more numerous lipid particles in the extracellular spaces. The results indicate that aortic lesions can be produced predictably after 8 weeks of feeding a high-cholesterol diet and that qualitative changes in the lesions occur 16 weeks after withdrawal from the diet.