Robust and reusable supported palladium catalysts for cross-coupling reactions in flow
Robust and reusable supported palladium catalysts for cross-coupling reactions in flow
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DOI：
10.1039/c3cy00836c
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发表时间：
2014-03
影响因子：
5
通讯作者：
W. Reynolds;P. Plucinski;C. Frost
中科院分区：
文献类型：
--
作者：
W. Reynolds;P. Plucinski;C. Frost
制备了两种新型聚合物包封的二氧化硅负载的钯催化剂，并显示出在连续流动条件下用于Heck和Suzuki-Miyaura交叉偶联反应的高活性、稳定性和可回收的催化剂。它们被证明可以提供优异的富电子和缺电子底物的转化率，并且催化剂用于超过50小时的连续操作，而没有任何明显的催化活性降低和通过ICP-MS测量的低水平的Pd浸出。
Two novel polymer encapsulated silica supported palladium catalysts have been prepared and shown to be highly active, robust and recyclable catalysts for Heck and Suzuki–Miyaura cross coupling reactions under continuous flow conditions. They were demonstrated to give excellent conversions of both electron rich and electron deficient substrates and the catalysts were used for over 50 hours continuous operation without any appreciable decrease in catalytic activity and low levels of Pd leaching measured by ICP-MS.