3D-Printed Gastric Resident Electronics
3D-Printed Gastric Resident Electronics
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DOI：
10.1002/admt.201800490
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发表时间：
2019-03-01
影响因子：
6.8
通讯作者：
Traverso, Giovanni
中科院分区：
文献类型：
--
作者：
Kong, Yong Lin;Zou, Xingyu;Traverso, Giovanni
将生物医学电子器件长期植入人体，可实现先进的诊断和治疗功能。然而，大多数长期驻留的电子设备需要用于植入的侵入性程序以及用于通信的专用接收器。这里，提出了一种胃驻留电子（GRE）系统，其利用由胃环境提供的解剖空间来使得这种设备的口服递送平台能够驻留在人体内。GRE能够通过蓝牙（一种广泛采用的无线协议）直接与便携式消费者个人电子产品接口。与先前的可摄取电子器件实现的被动的一整天的胃驻留相反，多材料原型的进步使GRE能够驻留在恶劣的胃环境中最多36天，并保持大约15天的无线电子通信，如猪模型中的研究所证明的。事实上，可重新配置的胃驻留结构、药物释放模块和无线电子器件的协同集成最终可以实现下一代远程诊断和自动化治疗策略。
Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day-long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain approximate to 15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric-residence structure, drug release modules, and wireless electronics could ultimately enable the next-generation remote diagnostic and automated therapeutic strategies.