THE BIOELECTRIC FACTORS IN AMPHIBIAN-LIMB REGENERATION
THE BIOELECTRIC FACTORS IN AMPHIBIAN-LIMB REGENERATION
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DOI：
10.2106/00004623-196143050-00002
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发表时间：
1961-01-01
影响因子：
5.3
通讯作者：
BECKER, RO
中科院分区：
文献类型：
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作者：
BECKER, RO
在蝾螈和青蛙中，以身体表面的直流电位测量的稳态电位被定义为生物电场或直流电场。截肢后立即由一个完全逆转的电极在残端。在再生过程中，最初的正极性下降，再次上升，然后下降并维持负电位，直到愈合完成。骨折愈合过程中的电压变化顺序与肢体再生过程中的电压变化顺序相同。断肢后外加电流可增加芽基的大小，加快再生速度。中枢神经系统的某些部分的直流活动构成了真正的数据传输和控制系统，并且该系统的输出参数之一是对涉及再生和修复的生长过程的控制。直流场系统的输出部分与由细胞活动产生的真正闭合回路有关。不太充分的愈合过程，如成年青蛙的截肢残端，与人类相同，并且不会产生伴随蝾螈肢体再生的特定序列的潜在变化。
In salamanders and frogs, a steady state potential, measured as direct current potentials on the surface of the body, is defined as the bioelectric or direct current field. Limb amputation was immediately followed by a complete reversal of electrical polarity at the stump. During regenerative processes, the initial positive polarity fell, rose again, then fell and sustained negative potential until healing was complete. The voltage change sequence during healing of a fracture was the same as during limb regeneration. Administration of external current after limb amputation increased the size of the blastema and accelerated the rate of regeneration. The direct-current activity of some portion of the central nervous system constitutes a true data transmission and control system and one of the output parameters of the system is the control of the growth processes involved in regeneration and repair. The output portion of the direct current field system is related to a true closed loop created by the activity of cells. Less adequate healing processes as in the amputation stump of the adult frog, are the same as in man, and do not produce the specific sequence of potential changes that accompany regeneration of the extremity of the salamander.