Granulocyte colony-stimulating factor attenuates oxidative stress-induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy
Granulocyte colony-stimulating factor attenuates oxidative stress-induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy
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DOI：
10.1182/blood-2010-05-286963
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发表时间：
2011-01-20
期刊：
影响因子：
20.3
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Kojima, Hiroshi;Otani, Atsushi;Yoshimura, Nagahisa
粒细胞集落刺激因子 (G-CSF) 是一种已知的造血糖蛋白，最近的研究表明 G-CSF 还具有其他有趣的特性。氧化应激与许多疾病有关，如动脉粥样硬化、心力衰竭、心肌梗塞、阿尔茨海默病和糖尿病视网膜病变。本研究旨在探讨G-CSF是否对内皮细胞对抗氧化应激具有保护作用，并探讨G-CSF是否对缺血性血管疾病具有治疗作用。 G-CSF 的表达 (P
Granulocyte colony-stimulating factor (G-CSF) is a known hematopoietic glycoprotein, and recent studies have revealed that G-CSF possesses other interesting properties. Oxidative stress is involved in many diseases, such as atherosclerosis, heart failure, myocardial infarction, Alzheimer disease, and diabetic retinopathy. This study was designed to examine whether G-CSF has a protective effect on endothelial cells against oxidative stress and to investigate whether G-CSF has a therapeutic role in ischemic vascular diseases. Expression of G-CSF (P