Association between risk of venous thromboembolism and mortality in patients with COVID-19.
Association between risk of venous thromboembolism and mortality in patients with COVID-19.
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COVID-19 患者静脉血栓栓塞风险与死亡率之间的关联
DOI：
10.1016/j.ijid.2021.06.005
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Chen S;Zheng T;Wang S;Yu Y;Wang P;Song Y;Jiang J
研究静脉血栓栓塞风险与COVID-19患者30天死亡率的相关性。共回顾性收集了1030名COVID-19患者，包括人口统计学、序贯器官衰竭评估（SOFA）评分和VTE风险评估模型（RAM）的基线数据，包括帕多瓦预测评分（PPS）、国际医学预防登记（IMPROVE）和Caprini。30天死亡率从低VTE风险患者的2%逐渐增加到PPS定义的高风险患者的63%。在IMPROVE和Caprini评分中观察到类似结果。VTE风险的进行性增加也与SOFA评分升高相关。无论调整性别、吸烟状况和某些合并症，VTE高风险与死亡率独立相关，PPS、IMPROVE和Caprini RAM的风险比分别为29.19、37.37和20.60（所有比较P < 0.001）。PPS（曲线下面积（AUC）0.900）、IMPROVE（AUC 0.917）或Caprini（AUC 0.861）RAM对住院死亡风险的预测准确性出乎意料地强。我们确定，VTE高风险的存在确定了一组死亡风险较高的COVID-19患者。此外，VTE RAM预测这些患者死亡率的准确性很高。
To investigate the association of risk of venous thromboembolism with 30-day mortality in COVID-19 patients. A total of 1030 COVID-19 patients were retrospectively collected, with baseline data on demographics, sequential organ failure assessment (SOFA) score, and VTE risk assessment models (RAMs), including Padua prediction score (PPS), International Medical Prevention Registry (IMPROVE), and Caprini. Thirty-day mortality increased progressively from 2% in patients at low VTE risk to 63% in those at high risk defined by PPS. Similar findings were observed in IMPROVE and Caprini scores. Progressive increases in VTE risk were also associated with higher SOFA score. High risk of VTE was independently associated with mortality regardless of adjusted gender, smoking status and some comorbidities, with hazard ratios of 29.19, 37.37 and 20.60 for PPS, IMPROVE and Caprini RAM, respectively (P < 0.001 for all comparisons). The predictive accuracy of PPS (area under curve (AUC) 0.900), IMPROVE (AUC 0.917), or Caprini (AUC 0.861) RAM for risk of hospitalized mortality was unexpectedly strong. We established that the presence of a high risk of VTE identifies a group of COVID-19 patients at higher risk for mortality. Furthermore, there is a high accuracy of VTE RAMs to predict mortality in these patients.
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影响因子：
10.4
作者：
Vardi, M.;Ghanem-Zoubi, N. O.;Bitterman, H.
通讯作者：
Bitterman, H.
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
120.7
作者：
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通讯作者：
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影响因子：
7.5
作者：
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通讯作者：
Wiercioch, Wojtek