Modern genome editing meets telomeres: the many functions of TPP1.
Modern genome editing meets telomeres: the many functions of TPP1.
复制标题
现代基因组编辑遇到端粒：TPP1 的多种功能。
DOI：
10.1101/gad.250316.114
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发表时间：
2014
影响因子：
10.5
通讯作者：
Karlseder,Jan
中科院分区：
文献类型：
--
作者：
Karlseder,Jan
The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.
