Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
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DOI：
10.1126/science.1072682
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发表时间：
2002-12-06
期刊：
影响因子：
56.9
通讯作者：
Lapadat, R
中科院分区：
文献类型：
--
作者：
Johnson, GL;Lapadat, R
多细胞生物有三个特征明确的丝裂原活化蛋白激酶亚家族，它们控制着大量的生理过程。这些酶是由一个特有的磷接力系统调节的，在这个系统中，一系列的三种蛋白激酶磷酸化并相互激活。细胞外信号调节激酶（ERKs）在控制细胞分裂中起作用，这些酶的抑制剂正在被探索作为抗癌药物。c-Jun氨基末端激酶（JNKs）是转录的关键调控因子，JNK抑制剂可能有效控制类风湿关节炎。p38 MAPKs可被炎症细胞因子和环境应激激活，并可能导致哮喘和自身免疫等疾病。
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.