The baculoviruses occlusion-derived virus: virion structure and function.
The baculoviruses occlusion-derived virus: virion structure and function.
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DOI：
10.1016/s0065-3527(06)69003-9
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发表时间：
2007
影响因子：
--
通讯作者：
Arif BM
中科院分区：
文献类型：
--
作者：
Slack J;Arif BM
杆状病毒在调节昆虫种群规模方面发挥着重要的生态作用。多年来，杆状病毒已被用作林业和农业害虫的靶向生物防治剂。杆状病毒杀虫剂对豆毛虫（Anticarsia gemmatalis）、棉铃虫（Helicoverpa zea）和舞毒蛾（Lymantria dispar）等害虫有效。杆状病毒通过咬合衍生病毒（ODV）介导的口腔途径传播给昆虫。 ODV 还专门用于利用昆虫中肠，这是最极端的生物环境之一，病毒在其中会受到腐蚀性 pH 值和消化蛋白酶的影响。 ODV 的分子生物学揭示了蛋白质化学的新领域。最后，ODV 在昆虫肠道组织中建立感染，这些组织实际上不支持病毒复制，并且会不断脱落。 ODV 携带一组蛋白质，使它们能够快速利用和利用这些不稳定的细胞进行病毒复制。
Baculoviruses play an important ecological role regulating the size of insect populations. For many years, baculoviruses have been applied as targeted biocontrol agents against forestry and agriculture pests. Baculovirus insecticides are effective against insect pests such as velvetbean caterpillar (Anticarsia gemmatalis), cotton bollworm (Helicoverpa zea), and gypsy moth (Lymantria dispar). Baculoviruses are transmitted to insects by the oral route mediated by the occlusion-derived virus (ODV). The ODV is also specialized to exploit the insect midgut that is one of the most extreme biological environments where the viruses are subject to caustic pH and digestive proteases. The molecular biology of the ODV reveals new frontiers in protein chemistry. Finally, ODVs establishes infection in insect gut tissues that are virtually nonsupportive to virus replication and which are continuously sloughed away. ODVs carry with them a battery of proteins that enable them to rapidly exploit and harness these unstable cells for virus replication.