Calculation of rates of immunologically determined accepted mutations (IDAM) for 6 primate plasma proteins.
Calculation of rates of immunologically determined accepted mutations (IDAM) for 6 primate plasma proteins.
复制标题
计算 6 种灵长类血浆蛋白的免疫学确定的接受突变 (IDAM) 率。
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
K. Bauer
中科院分区：
文献类型：
--
作者：
K. Bauer
在氨基酸水平上对6种灵长类血浆蛋白的免疫学决定的接受突变(IDAM)率与接受点突变(PAM)率进行估算的可能性被证明。描述了比较行列式分析，并与较旧的技术进行了比较。讨论了这项技术及其局限性，以及多肽区域必须满足的条件，才能成为与特定抗体结合的抗原决定簇。以这种方式获得的IDAM比率在每100个残基和1亿年的0.70到8.35之间。给出了IDAM和PAM费率的比较。
The possibility to estimate the rates of immunologically determined accepted mutations (IDAMs) in analogy to accepted point mutation (PAM) rates at the amino acid level is demonstrated for 6 primate plasma proteins. The comparative determinant analysis is described and compared with older techniques. The technique and its limitations are discussed as are the conditions a polypeptide region must fulfill to become an antigenic determinant binding to a specific antibody. IDAM rates obtained this way range between 0.70 and 8.35 per 100 residues and 100 million years. Comparisons between IDAM and PAM rates are given.