Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.
Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.
复制标题
DOI：
10.1021/jacs.9b12421
复制
发表时间：
2020-01
影响因子：
15
通讯作者：
Gang‐Wei Wang;Olivia Boyd;Tom A. Young;Sophie M. Bertrand;J. Bower
中科院分区：
文献类型：
--
作者：
Gang‐Wei Wang;Olivia Boyd;Tom A. Young;Sophie M. Bertrand;J. Bower
我们概述了一个概念蓝图，为广泛的复杂多杂环提供了直接和原子经济的途径。我们的方法利用了环丙烷暴露于Rh(I)催化剂和CO时产生的红代环戊酮的亲性反应性。使用这种方法，实现了广泛的多环化，包括涉及强脱芳化和中等环形成的变体。
We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.