NATURE OF RECOMBINATION INVOLVED IN EXCISION AND REARRANGEMENT OF HUMAN REPETITIVE DNA
NATURE OF RECOMBINATION INVOLVED IN EXCISION AND REARRANGEMENT OF HUMAN REPETITIVE DNA
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DOI：
10.1016/0022-2836(87)90202-6
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发表时间：
1987-12-20
影响因子：
5.6
通讯作者：
OISHI, M
中科院分区：
文献类型：
--
作者：
KIYAMA, R;OKUMURA, K;OISHI, M
Sau3A 家族的类似阿尔菲的人类重复 DNA 存在于染色体外和染色体中。在染色体中，DNA位于11号染色体上，但相关序列存在于17号染色体上。我们表征了从11号染色体上切除染色体外DNA所涉及的重组的性质。结果表明，重组既发生在同源亚基之间，也发生在异源亚基之间，它们之间只有70%至80%的序列同源性，表明序列同源性以外的DNA结构介导了重组过程。相同类型的重组导致 17 号染色体中相关序列的重排。
An alphoid-like human repetitive DNA of the Sau3A family is present extrachromosomally and in the chromosomes. In the chromosomes, the DNA is located on chromosome 11 but related sequences are present in chromosome 17. We characterized the nature of the recombination involved in the excision of the extrachromosomal DNA from chromosome 11. The results show that the recombination occurs both between the homologous subunits and between the heterologous subunits with only a 70 to 80% sequence homology among them, suggesting that a DNA structure other than a sequence homology mediates the recombination process. The same type of recombination is responsible for the rearrangement of the related sequences in chromosome 17.