Myelination shapes functional activity in the developing brain
Myelination shapes functional activity in the developing brain
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DOI：
10.1016/j.neuroimage.2007.07.010
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发表时间：
2007-11-15
期刊：
影响因子：
5.7
通讯作者：
Maeder, Philippe
中科院分区：
文献类型：
--
作者：
Fornari, Eleonora;Knyazeva, Maria G.;Maeder, Philippe
在人类中，空间整合（SI）的功能发展缓慢，持续通过童年到青春期。为了揭示其在儿童中的神经基质，并研究髓鞘形成在塑造SI依赖性功能活动中的作用，我们应用了能够跟踪功能（BOLD反应）和形态（髓鞘形成）成熟迹象的组合fNIRI/MTI技术。14名儿童（7-13岁）在观看双侧光栅时进行了扫描，这些光栅要么遵守完形分组规则，要么违反规则。这些刺激之间的对比揭示了BOLD反应，推测是由半球间SI引起的。它仅限于舌回中的一个小腹侧流区域，该区域对应于成人VP/V4区域中SI诱导激活的VP部分。BOLD反应与压纤维髓鞘形成有关。这些数据表明，激活的纹外区，使SI功能取决于长距离皮质-皮质连接的成熟。(c)2007年爱思唯尔公司All rights reserved.
In humans, the function of spatial integration (SI) develops slowly, continuing through childhood into adolescence. To reveal its neural substrate in children and to examine the role of myelination in shaping SI-dependent functional activity, we applied a combined fNIRI/MTI technique capable of tracking functional (BOLD response) and morphological (myelination) signs of maturation. Fourteen children (age 7-13) were scanned while viewing bilateral gratings, which either obeyed Gestalt grouping rules or violated them. A contrast between these stimuli revealed the BOLD response presumably induced by interhemispheric SI. It was limited to a small ventral stream territory in the lingual gyrus that corresponds to the VP part of the SI-induced activation found in adults in VP/V4 areas. The BOLD response correlated with myelination of splenial fibers. The data suggest that the activation of the extrastriate areas that enable an SI function depends on the maturation of long-range cortico-cortical connections. (c) 2007 Elsevier Inc. All rights reserved.