DIAZOXIDE IN THE MANAGEMENT OF PATIENTS WITH INSULINOMA
DIAZOXIDE IN THE MANAGEMENT OF PATIENTS WITH INSULINOMA
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DOI：
10.1007/bf01655532
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发表时间：
1986-08-01
影响因子：
2.6
通讯作者：
MORTE, JA
中科院分区：
文献类型：
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作者：
GOODE, PN;FARNDON, JR;MORTE, JA
控制胰腺胰岛素分泌型胰岛肿瘤（胰岛素瘤）患者的严重低血糖症状是治疗的一个重要方面。一系列的24例胰岛素瘤患者的年龄范围从5个月至73岁，在一个中心超过17年的时间内进行了描述。目前的症状和这些对他们的生活方式的影响进行了讨论。二氮嗪已被用于控制24例患者中的18例的低血糖症状。14例患者在成功手术前接受了不同时间段的二氮嗪治疗，4例患者接受了长期治疗。这些患者中的三个突出显示使用二氮嗪的益处和问题的各个方面。二氮嗪的平均剂量为400 mg/天，平均治疗时间为10个月。症状控制良好8例，可6例，差4例。观察到的主要副作用是多毛症（56%）、踝关节水肿（50%）、体重增加（38%）和恶心（11%）。这些副作用耐受良好，治疗的好处被认为超过缺点。仅1例发生严重超敏反应的患者因副作用而需要停用二氮嗪。我们的研究结果表明，二氮嗪在胰岛素瘤患者术前肿瘤定位的管理中发挥了作用，也可以用于手术禁忌或剖腹手术不成功时。
The control of severe hypoglycemic symptoms in patients with insulin‐secreting islet tumors (insulinoma) of the pancreas is an important aspect of management. A series of 24 patients with insulinomas whose ages ranged from 5 months to 73 years seen at one center over a period of 17 years is described. The presenting symptoms and the effect of these on their lifestyles are discussed. Diazoxide has been used to control hypoglycemic symptoms in 18 of the 24 patients. Fourteen patients have received diazoxide for varying periods of time prior to successful surgery and 4 have received long‐term therapy. Three of these patients are highlighted to show various aspects of benefit and problems from the use of diazoxide. The mean dosage of diazoxide was 400 mg/day and the mean duration of therapy was 10 months. The control of symptoms was good in 8, fair in 6, and poor in 4. The main side effects observed were hirsutism (56%), ankle edema (50%), weight gain (38%), and nausea (11%). These side effects were well tolerated and the benefits of therapy were felt to outweigh disadvantages. Side effects only necessitated discontinuation of diazoxide in 1 patient who developed a severe hypersensitivity reaction. Our results show that diazoxide has a role to play in the management of patients with insulinoma during preoperative tumor localization and can also be used when surgery is contraindicated or when laparotomy is unsuccessful.