G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits
G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits
复制标题
DOI：
10.1016/j.bbrc.2006.03.081
复制
发表时间：
2006-05-26
影响因子：
3.1
通讯作者：
Komuro, I
中科院分区：
文献类型：
--
作者：
Hasegawa, H;Takano, H;Komuro, I
粒细胞集落刺激因子（G-CSF）可预防心肌梗死后左室重构，但其对动脉粥样硬化的影响尚不清楚。我们研究了两种家兔动脉粥样硬化模型。用G-CSF或生理盐水对14月龄的有心肌梗死倾向的Watanabe遗传性高脂血症（WHHL-MI）家兔进行7天治疗。采用球囊扩张法建立兔髂动脉血管损伤模型，分为G-CSF组和生理盐水组。G-CSF治疗4周后可显著降低WHHL-MI兔冠状动脉狭窄评分和胸主动脉脂质斑块面积。在血管损伤模型中，G-CSF在治疗后4周显著防止了新生内膜/中膜比率的增加。G-CSF可促进动脉再内皮化，而一氧化氮合酶抑制剂可明显抑制G-CSF的作用，提示G-CSF对动脉粥样硬化有治疗作用。(c)2006年爱思唯尔公司All rights reserved.
Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis. (c) 2006 Elsevier Inc. All rights reserved.