Intestinal migrating myoelectric complexes in rats with acute pancreatitis and bile duct ligation.
Intestinal migrating myoelectric complexes in rats with acute pancreatitis and bile duct ligation.
复制标题
急性胰腺炎和胆管结扎大鼠的肠道迁移肌电复合体。
DOI：
10.1006/jsre.1993.1127
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Moody,FG
中科院分区：
文献类型：
--
作者：
Li,YF;Newton,TJ;Weisbrodt,NW;Moody,FG
本文研究了胆总管结扎大鼠小肠移行性复合肌电（MMC）。将四对双极电极植入21只大鼠的空肠和回肠。在进行电记录之前，允许动物恢复7天。在十二指肠入口处（低）或胰腺上方（高）或假手术进行胆管结扎。分别于术前、术后48 h和72 h记录MMC。MMC间期在高位结扎或假手术后无变化。但低位胆管结扎后48小时MMC间期（20.6 ± 2.5）min较结扎前（14.0 ± 1.2）min明显延长。结扎后72小时观察到进一步延长的间期（28.4 ± 4.2 min）。任何动物组的慢波频率均无显着差异，范围为34.1 ± 1.1至36.3 ± 1.0周/分钟。因此，该大鼠模型中的MMC模式可能受到急性胰腺炎发展的影响。负责改变MMC模式的机制尚不清楚;然而，单独的肝胆汁分泌似乎不起主要作用。
Intestinal migrating myoelectric complexes (MMC) were studied in rats subjected to common bile duct ligation. Four pairs of bipolar electrodes were implanted on the jejunum and the ileum of 21 rats. Animals were allowed to recover 7 days before electrical recordings were made. Bile duct ligation at the entrance to the duodenum (low) or above the pancreas (high) or sham operation was performed. MMCs were recorded before and 48 and 72 hr after the operation in each animal. MMC intervals were unchanged following high ligation or sham operation. However, 48 hr after low bile duct ligation, the MMC interval (20.6 ± 2.5 min) was significantly prolonged compared with that before ligation (14.0 ± 1.2 min). Further prolonged intervals (28.4 ± 4.2 min) were observed 72 hr after the ligation. There were no significant differences among the slow wave frequencies in any group of animals, being in the range of 34.1 ± 1.1 to 36.3 ± 1.0 cycles/min. Thus, the MMC pattern in this rat model may be affected by the development of acute pancreatitis. The mechanism(s) responsible for altering the MMC pattern are not known; however, hepatic biliary secretion alone does not appear to play a primary role.