Medical management of aldosterone-producing adenomas
Medical management of aldosterone-producing adenomas
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DOI：
10.7326/0003-4819-131-2-199907200-00005
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发表时间：
1999-07-20
影响因子：
39.2
通讯作者：
Bravo, EL
中科院分区：
文献类型：
--
作者：
Ghose, RP;Hall, PM;Bravo, EL
背景资料：没有数据可供长期医疗管理的醛固酮腺瘤。目的：证明医疗管理的醛固酮腺瘤的血压和血清钾浓度方面的疗效，并讨论与医疗management.Design相关的发病率：回顾性队列研究。设定：大型三级医疗转诊中心。患者：24例经医学治疗至少5年的有记录的醛固酮腺瘤患者。测量：醛固酮排泄率，血浆肾素活性，腺瘤的大小和位置（通过计算机断层扫描）。在诊断和末次随访时测量血压和血清电解质。从诊断到最后一次随访，收缩压从175 mm Hg降至129 mm Hg（差异的95% CI，37.1至53.8 mm Hg），舒张压从106 mm Hg降至79 mm Hg（差异的CI，20.8至33.9 mm Hg）。血清钾浓度从3.0 mmol/L增加到4.3 mmol/L（差异CI，1.1至1.5 mmol/L）。结论：醛固酮腺瘤的药物治疗是控制血压和血清钾浓度的可行选择。
Background: No data are available on the long-term medical management of aldosterone-producing adenomas.Objective: To demonstrate the efficacy of medical management of aldosterone-producing adenomas in terms of blood pressure and serum potassium concentration and to discuss morbidity associated with medical management.Design: Retrospective cohort study. Setting: Large tertiary care referral center.Patients: 24 patients with documented aldosterone-producing adenomas who were treated medically for at least 5 years.Measurements: Aldosterone excretion rate, plasma renin activity, and size and location of adenomas (by computed tomography). Blood pressure and serum electrolytes were measured at the time of diagnosis and last follow-up.Results: From the time of diagnosis to the time of last follow-up, systolic blood pressure decreased from 175 mm Hg to 129 mm Hg (95% CI for difference, 37.1 to 53.8 mm Hg) and diastolic blood pressure decreased from 106 mm Hg to 79 mm Hg (CI for difference, 20.8 to 33.9 mm Hg). Serum potassium concentration increased from 3.0 mmol/L to 4.3 mmol/L (CI for difference, 1.1 to 1.5 mmol/L).Conclusions: Medical management of aldosterone-producing adenomas is a viable option for controlling blood pressure and serum potassium concentration.