Oligodendrocyte progenitor cell fate and function in development and disease.
Oligodendrocyte progenitor cell fate and function in development and disease.
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DOI：
10.1016/j.ceb.2021.05.003
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发表时间：
2021-12
影响因子：
7.5
通讯作者：
Tesar PJ
中科院分区：
文献类型：
--
作者：
Clayton BLL;Tesar PJ
Differentiation of oligodendrocyte progenitor cells (OPC) into myelination capable mature oligodendrocytes is essential for proper function of the central nervous system (CNS). OPCs are tissue resident stem cells that populate all regions of the CNS and exist beyond development into adulthood. Disorders that lead to disruption of this critical cell state change cause devastating myelin diseases that are often associated with shortened lifespan. Recent findings have also provided support for a newly appreciated contribution of perturbed OPC differentiation to neurodegenerative and psychiatric diseases. These findings emphasize the need for a more complete understanding of OPC differentiation in health and disease. Here we review recent molecular and functional findings revealing new roles of OPCs. It is our hope that this review provides readers with an enticing snapshot of current OPC research and highlights the potential of controlling OPC fate and function to treat diseases of the brain.
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影响因子：
11
作者：
de Vrij FM;Bouwkamp CG;Gunhanlar N;Shpak G;Lendemeijer B;Baghdadi M;Gopalakrishna S;Ghazvini M;Li TM;Quadri M;Olgiati S;Breedveld GJ;Coesmans M;Mientjes E;de Wit T;Verheijen FW;Beverloo HB;Cohen D;Kok RM;Bakker PR;Nijburg A;Spijker AT;Haffmans PMJ;Hoencamp E;Bergink V;GROUP Study Consortium;Vorstman JA;Wu T;Olde Loohuis LM;Amin N;Langen CD;Hofman A;Hoogendijk WJ;van Duijn CM;Ikram MA;Vernooij MW;Tiemeier H;Uitterlinden AG;Elgersma Y;Distel B;Gribnau J;White T;Bonifati V;Kushner SA
通讯作者：
Kushner SA
影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
影响因子：
64.8
作者：
Hubler Z;Allimuthu D;Bederman I;Elitt MS;Madhavan M;Allan KC;Shick HE;Garrison E;T Karl M;Factor DC;Nevin ZS;Sax JL;Thompson MA;Fedorov Y;Jin J;Wilson WK;Giera M;Bracher F;Miller RH;Tesar PJ;Adams DJ
通讯作者：
Adams DJ
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G
影响因子：
25
作者：
Grubman, Alexandra;Chew, Gabriel;Polo, Jose M.
通讯作者：
Polo, Jose M.