Early development of the lower deciduous dentition and oral vestibule in human embryos
Early development of the lower deciduous dentition and oral vestibule in human embryos
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DOI：
10.1111/j.1600-0722.2007.00464.x
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发表时间：
2007-08-01
影响因子：
1.9
通讯作者：
Peterkova, Renata
中科院分区：
文献类型：
--
作者：
Hovorakova, Maria;Lesot, Herve;Peterkova, Renata
本工作的目的是研究人类胚胎下颌的乳牙期和口腔前庭的早期发育。应用组织学切片和产前6~9周的三维重建。口腔前庭的连续原骨在下颌骨中不存在。与我们以前观察到的上颌骨不同，在上颌骨，牙齿和前庭上皮细胞分别发育，两个齿状前庭突起在下颌切牙区域分化。每个凸起的舌部形成各自的中央切牙和侧切牙，而唇部分化为前庭上皮。在尖牙和磨牙区，牙上皮和前庭上皮分别起源。后来，前庭上皮的节段融合到唇前庭脊内，形成唇区的下口腔前庭。在面颊部位，口腔前庭起源于发育中的颌骨和面颊之间的粘膜弯曲。在上颌中也观察到了类似的口腔前庭的异质性发育基础。因此，对于牙齿和前庭上皮的早期发育，没有适用于上颌和下颌，以及它们的前部和后部的一般方案。
The aim of this work was to investigate the early development of the deciduous dentition and oral vestibule in the human embryonic lower jaw. Histological sections and three-dimensional reconstructions from prenatal weeks 6-9 were used. A continuous anlage for the oral vestibule did not exist in the mandible. In contrast to the upper jaw, where we previously observed that the dental and vestibular epithelia developed separately, two dento-vestibular bulges differentiated in the incisor region of the mandible. The lingual parts of each bulge were found to give rise to the respective central and lateral incisors, whereas the labial parts differentiated into the vestibular epithelium. In the canine and molar areas, the dental and vestibular epithelia originated separately. Later, the segments of the vestibular epithelium fused into the labial vestibular ridge, giving rise to the lower oral vestibule in the lip region. In the cheek region, the oral vestibule was found to originate in the mucosal inflection between the developing jaw and the cheek. A similar heterogenous developmental base for the oral vestibule was also observed in the upper jaw. There is thus no general scheme for the early development of the dental and vestibular epithelia that applies to both the upper and lower jaws, and to both their anterior and posterior regions.