Inhibition of angiogenesis by propolis
Inhibition of angiogenesis by propolis
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DOI：
10.1007/bf02976609
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发表时间：
2002-08-01
影响因子：
6.7
通讯作者：
Jin, CB
中科院分区：
文献类型：
--
作者：
Song, YS;Park, EH;Jin, CB
蜂胶，从蜂巢中获得，已被用于东方民间医药作为抗炎，抗癌和免疫调节剂。有相当多的证据表明，血管生成和慢性炎症是相互依赖的。血管生成的阻断导致抗炎作用。采用鸡胚绒毛尿囊膜（CAM）和小牛肺动脉内皮细胞（CPAE）检测了蜂胶乙醇（EEP）和乙醚提取物（REP）以及蜂胶活性成分咖啡酸苯乙酯（CAPE）的抗血管生成活性。细胞增殖，测定。EEP REP和CAPE的存在抑制CAM测定中的血管生成和CPAE细胞的增殖。结果提示，EEP、REP和CAPE的抗炎作用与其抗血管生成活性有关。
Propolis, obtained from honeybee hives, has been used in Oriental folk medicine as an anti-inflammatory, anti-carcinogenic, and immunomodulatory agent. There is considerable evidence suggesting that angiogenesis and chronic inflammation are codependent. Blockage of angiogenesis results in an anti-inflammatory effect. Ethanol (EEP) and ether extracts of propolis (REP), and caffeic acid phenethyl ester (CAPE), an active component of propolis, were examined for their anti-angiogenic activities using the chick embryo chorioallantoic membrane (CAM), and the calf pulmonary arterial endothelial (CPAE) cell proliferation, assays. The presence of EEP REP and CAPE inhibited angiogenesis in the CAM assay and the proliferation of CPAE cells. The results suggest that anti-angiogenic activities of EEP, REP and CAPE are also responsible for their anti-inflammatory effect.