High-resolution mapping defines the cooperative architecture of Polycomb response elements.
High-resolution mapping defines the cooperative architecture of Polycomb response elements.
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DOI：
10.1101/gr.163642.113
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发表时间：
2014-05
期刊：
影响因子：
7
通讯作者：
Ahmad K
中科院分区：
文献类型：
--
作者：
Orsi GA;Kasinathan S;Hughes KT;Saminadin-Peter S;Henikoff S;Ahmad K
Polycomb-mediated chromatin repression modulates gene expression during development in metazoans. Binding of multiple sequence-specific factors at discrete Polycomb response elements (PREs) is thought to recruit repressive complexes that spread across an extended chromatin domain. To dissect the structure of PREs, we applied high-resolution mapping of nonhistone chromatin proteins in native chromatin of Drosophila cells. Analysis of occupied sites reveal interactions between transcription factors that stabilize Polycomb anchoring to DNA, and implicate the general transcription factor ADF1 as a novel PRE component. By comparing two Drosophila cell lines with differential chromatin states, we provide evidence that repression is accomplished by enhanced Polycomb recruitment both to PREs and to target promoters of repressed genes. These results suggest that the stability of multifactor complexes at promoters and regulatory elements is a crucial aspect of developmentally regulated gene expression.
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DOI：
10.1016/j.cub.2009.02.055
发表时间：
2009-04-28
期刊：
Current biology : CB
影响因子：
--
作者：
Chopra VS;Hong JW;Levine M
通讯作者：
Levine M
DOI：
10.1073/pnas.0701538104
发表时间：
2007-10-16
影响因子：
11.1
作者：
Beisel, Christian;Buness, Andreas;Paro, Renato
通讯作者：
Paro, Renato
影响因子：
7
作者：
Enderle, Daniel;Beisel, Christian;Paro, Renato
通讯作者：
Paro, Renato
模因套件：用于发现和搜索的工具。
影响因子：
14.9
作者：
Bailey TL;Boden M;Buske FA;Frith M;Grant CE;Clementi L;Ren J;Li WW;Noble WS
通讯作者：
Noble WS
影响因子：
11.4
作者：
Déjardin, J;Cavalli, G
通讯作者：
Cavalli, G