Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum.
Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum.
复制标题
细胞粘菌盘基网柄菌中趋化反应的信号输入。
DOI：
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发表时间：
1975
影响因子：
11.1
通讯作者：
T. M. Konijn
中科院分区：
文献类型：
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作者：
J. Mato;A. Losada;V. Nanjundiah;T. M. Konijn
将含有不同浓度的 3':5'-环 AMP 的液滴沉积在距离盘基网柄菌阿米巴小群体不同距离的位置，并确定 50% 的阿米巴变形虫液滴发生阳性反应的距离。距离与浓度的对数图的线性回归分析给出了一条斜率为 1/4.25 的直线，该值表明变形虫对环 AMP 浓度的空间梯度有反应。信号的阈值为3.6 X 10(-9) M/mm，测量灵敏度约为1%。这些发现与我们目前对环 AMP 受体的了解有关。
Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance against concentration gives a straight line with a slope of 1/4.25, which value suggests that the amoebae respond to a spatial gradient of cyclic AMP concentration. The threshold value for the signal is 3.6 X 10(-9) M/mm with a sensitivity of measurement of about 1%. These findings are discussed in relation to our present knowledge of cyclic AMP receptors.