Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report
Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report
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DOI：
10.1002/hed.23917
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Ren, Jihao
中科院分区：
文献类型：
--
作者：
Xie, Shumin;Liu, Wei;Ren, Jihao
背景。原发性甲状腺淋巴瘤（PTL）并不常见，占所有甲状腺恶性肿瘤的 2% 至 5%。甲状腺乳头状癌（PTC）是最常见的甲状腺癌。 PTL与PTC同时存在的情况非常罕见，术前诊断也相当困难。方法。一名41岁男性患者主诉快速无痛性甲状腺肿大2个月，宫颈肿块半个月就诊。影像学显示甲状腺肿大，甲状腺内有肿块。结果。进行了手术，并通过组织病理学和免疫组化检查最终诊断为PTL和PTC共存。随后，患者接受了环磷酰胺、羟基阿霉素、致癌蛋白、泼尼松 (CHOP) 化疗和放疗。随访2个月，未见复发、转移。结论。这一罕见病例凸显了医生牢记 PTL 对甲状腺突然肿大且有桥本甲状腺炎临床病史的患者进行鉴别诊断的重要性。 (c) 2015 年 Wiley 期刊公司。
Background. Primary thyroid lymphoma (PTL) is uncommon, accounting for 2% to 5% of all thyroid malignancies. Papillary thyroid carcinoma (PTC) is the most frequent thyroid cancer. The coexistence of PTL and PTC is very rare, and the preoperative diagnosis is rather difficult.Methods. A 41-year-old male patient complaining of fast painless thyroid enlargement for 2 months and a cervical mass for half a month was presented. Imaging demonstrated an enlarged thyroid and a mass in the thyroid.Results. Surgery was conducted, and the final diagnosis of coexistence of PTL and PTC was confirmed by histopathological and immunohistochemical examination. The patient was then treated with cyclophosphamide, hydroxy doxorubicin, oncovin, prednisone (CHOP) chemotherapy and radiotherapy. After 2 months of follow-up, no recurrence or metastasis was noted.Conclusion. This rare case highlights the importance for physicians to keep PTL in mind for differential diagnosis in patients with sudden thyroid enlargement and who have clinical history of Hashimoto thyroiditis. (c) 2015 Wiley Periodicals, Inc.