Planum temporale and Heschl gyrus volume reduction in schizophrenia -: A magnetic resonance imaging study of first-episode patients
Planum temporale and Heschl gyrus volume reduction in schizophrenia -: A magnetic resonance imaging study of first-episode patients
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DOI：
10.1001/archpsyc.57.7.692
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发表时间：
2000-07-01
影响因子：
--
通讯作者：
Shenton, ME
中科院分区：
文献类型：
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作者：
Hirayasu, Y;McCarley, RW;Shenton, ME
背景资料：精神分裂症的磁共振成像研究揭示了颞叶结构的异常，包括上级颞回。更具体地说，在后上级颞回，其中包括Heschl回和颞平面，后者是语言的重要基板异常已被报道。然而，海施尔回和颞平面结构异常对精神分裂症与情感性精神病的特异性，以及慢性发病率和神经安定药治疗可能的混淆作用仍不清楚。方法;：使用1.5T磁体采集20例首次发病的患者的磁共振图像（首次住院时）精神分裂症患者（平均年龄，27.3岁），24例躁狂性精神病首次发作患者（平均年龄，23.6岁）和22例对照（平均年龄，24.5岁）。3组的年龄无显著差异。结果：3组患者左侧颞平面的灰质体积不同。精神分裂症患者左颞平面容积显著小于正常对照组（20.0%）和躁狂症患者（20.0%）。与对照组（13.1%）和双相躁狂患者（16.8%）相比，精神分裂症患者的左右Heschl回灰质体积也减少。结论：与对照组和双相躁狂患者相比，首发精神分裂症患者的左侧颞平面灰质体积减少，双侧Heschl回灰质体积减少。这些发现与慢性精神分裂症患者中报告的结果相似，表明这种异常存在于首次发作时，并且是精神分裂症特有的。
Background: Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear.Methods;: Magnetic resonance images were acquired using a 1.5-T magnet from 20 first-episode (at first hospitalization) patients with schizophrenia (mean age, 27.3 years), 24 first-episode patients with manic psychosis (mean age, 23.6 years), and 22 controls (mean age, 24.5 years). There was no significant difference in age for the 3 groups. All brain images were uniformly aligned and then reformatted and resampled to field isotropic voxels.Results: Gray matter volume of the left planum temporale differed among the 3 groups. The patients with schizophrenia had significantly smaller left planum temporale volume than controls (20.0%) and patients with mania (20.0%). Heschl gyrus gray matter volume (left and right) was also reduced in patients with schizophrenia compared with controls (13.1%) and patients with bipolar mania (16.8%).Conclusions: Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matter volume reduction. These findings are similar to those reported in patients with chronic schizophrenia and suggest that such abnormalities are present at first episode and are specific to schizophrenia.