Percentage of Circulating CD8+T Lymphocytes is Associated with Albuminuria in Type 2 Diabetes Mellitus
Percentage of Circulating CD8+T Lymphocytes is Associated with Albuminuria in Type 2 Diabetes Mellitus
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DOI：
10.1055/s-0033-1358666
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发表时间：
2014-01-01
影响因子：
1.8
通讯作者：
Wang, Y.
中科院分区：
文献类型：
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作者：
Lei, L.;Mao, Y.;Wang, Y.
已证明T淋巴细胞在糖尿病蛋白尿的发展中起作用。然而，循环T淋巴细胞的改变还没有在2型糖尿病队列中进行研究。在北京大学航天中心医院进行了横断面研究。510例受试者均为2型糖尿病患者，年龄30-70岁。排除了免疫疾病、影响免疫功能的医疗状况、感染或终末器官损伤的患者。循环中CD 8 + T淋巴细胞的百分比与队列中的白蛋白尿显著相关。在多元线性回归模型中，白蛋白尿对CD 8 + T淋巴细胞的影响由B系数（95%置信区间）1.812（0.204-3.421，P=0.03）表示。我们的数据首次表明，循环中的CD 8 + T细胞的百分比与2型糖尿病患者的蛋白尿相关，这可能支持全身抑制T淋巴细胞治疗这些患者的蛋白尿的合理性。
T lymphocytes have been demonstrated to play a role in the development of diabetic proteinuria. However, the alteration of circulating T lymphocytes has not been investigated in a type 2 diabetic cohort. A cross-sectional study was conducted in Peking University Aerospace Center Hospital. 510 participants were type 2 diabetes mellitus, 30-70 years of age. Patients with immune disease, medical conditions that affect immune function, infection, or end-organ damage were excluded. The percentage of circulating CD8+ T lymphocytes was significantly associated with albuminuria in the cohort. The impact of albuminuria to CD8+ T lymphocytes in a multivariate linear regression model was indicated by the B-coefficient (95% confidence interval) 1.812 (0.204-3.421, P=0.03). Our data first showed that the percentage of circulating CD8+ T cells is associated with albuminuria in type 2 diabetes mellitus, which may support the rationality of systemic inhibition of T lymphocytes in treating albuminuria in these patients.