What is the best strategy to combat low bone mineral density in functional hypothalamic amenorrhea?
What is the best strategy to combat low bone mineral density in functional hypothalamic amenorrhea?
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对抗功能性下丘脑性闭经低骨密度的最佳策略是什么？
DOI：
10.1038/ncpendmet0925
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发表时间：
2008
影响因子：
--
通讯作者：
Misra,Madhusmita
中科院分区：
文献类型：
--
作者：
Misra,Madhusmita
功能性下丘脑闭经 (FHA) 与骨密度低和骨量增长率降低有关，特别是在严重营养不良的情况下，例如神经性厌食症。除了直接骨折风险之外，年轻女性骨代谢受损的发现引起了人们对峰值骨量减少的担忧，而峰值骨量是晚年骨骼健康的重要决定因素。因此，适当治疗 FHA 对于恢复 BMD 和骨量增长至关重要。维斯科维特等人。对文献进行了系统回顾，以评估旨在逆转 FHA 女性骨质流失的治疗策略。在本实践要点评论中，我讨论了激素和非激素疗法在多大程度上有益于优化骨骼健康。此外，我强调体重增加和生殖功能恢复对于患有 FHA 的女性保持骨骼健康的重要性。
Functional hypothalamic amenorrhea (FHA) is associated with low BMD and decreased rates of bone mass accrual, particularly in conditions of severe undernutrition, such as anorexia nervosa. In addition to immediate fracture risk, the finding of impaired bone metabolism in young women raises concerns about reduced peak bone mass, an important determinant of bone health in later life. Appropriate treatment of FHA is, therefore, crucial for restoration of BMD and for bone mass accrual. Vescoviet al. have performed a systematic review of the literature in order to assess therapeutic strategies that aim to reverse bone loss in women with FHA. In this Practice Point commentary, I discuss the extent to which hormonal and nonhormonal therapies have, or have not, been beneficial in optimizing bone health. In addition, I emphasize the importance of weight gain and recovery of reproductive function in the preservation of bone health in women with FHA.