Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus
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DOI：
10.1128/aac.01394-06
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发表时间：
2007-08-01
影响因子：
4.9
通讯作者：
Perfect, John R.
中科院分区：
文献类型：
--
作者：
Steinbach, William J.;Cramer, Robert A., Jr.;Perfect, John R.
钙调磷酸酶突变或抑制增强了细胞壁抑制剂卡泊芬净或尼可霉素Z对烟曲霉的抗真菌形态学效应。1，3-β-D-葡聚糖的定量显示钙调神经磷酸酶A（AcnaA）突变体的含量降低。钙调神经磷酸酶与其他细胞壁抑制剂联合应用可成为抗A.烟熏。
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillusfumigatus. Quantification of 1,3-beta-D-glucan revealed decreased amounts in the calcineurin A (AcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.