Cytotoxic withanolides from the flowers of Datura metel
Cytotoxic withanolides from the flowers of Datura metel
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DOI：
10.1021/np070096b
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发表时间：
2007-07-01
影响因子：
5.1
通讯作者：
Hu, Xianming
中科院分区：
文献类型：
--
作者：
Pan, Yuanhu;Wang, Xiaochuan;Hu, Xianming
对曼陀罗花的甲醇提取物进行化学研究，分离出 10 种新的睡茄内酯，即睡茄内酯 I-P (1-8)、1,10-seco-withametelin B (9) 和 12 β-羟基-1,10-seco-withametelin B (10)，以及 7 种已知的睡茄内酯。通过光谱方法阐明了1-10的结构，并通过单晶X射线分析证实了1的绝对立体化学。化合物1、3、4和6对A549（肺）、BGC-823（胃）和K562（白血病）癌细胞系表现出细胞毒活性，IC50值范围为0.05至3.5 muM。
Chemical investigation of a methanol extract of the flowers of Datura metel has led to the isolation of 10 new withanolides, withametelins I-P (1-8), 1,10-seco-withametelin B (9), and 12 beta-hydroxy-1,10-seco-withametelin B ( 10), together with seven known withanolides. The structures of 1-10 were elucidated by means of spectroscopic methods, and the absolute stereochemistry of 1 was confirmed by single-crystal X-ray analysis. Compounds 1, 3, 4, and 6 exhibited cytotoxic activities against A549 (lung), BGC-823 (gastric), and K562 (leukemia) cancer cell lines, with IC50 values ranging from 0.05 to 3.5 mu M.