ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN
ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN
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DOI：
10.1126/science.145.3633.719
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
DRACHMAN, DB
中科院分区：
文献类型：
--
作者：
DRACHMAN, DB
将肉毒毒素以大剂量静脉注射给7天和12天的鸡胚。骨骼肌萎缩导致其他器官无明显萎缩。肌肉组织学表现与失神经支配一致。结果提示，神经乙酰胆碱释放在神经-肌肉营养传递中起重要作用。
Botulinum toxin was given in large intravenous doses to 7- and 12-day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest tha neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.