MUSCARINIC CHOLINERGIC STIMULATION INCREASES CYCLIC GMP LEVELS IN RAT HIPPOCAMPUS 1
MUSCARINIC CHOLINERGIC STIMULATION INCREASES CYCLIC GMP LEVELS IN RAT HIPPOCAMPUS 1
复制标题
毒蕈碱胆碱能刺激增加大鼠海马 1 中的循环 GMP 水平
DOI：
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发表时间：
1979
影响因子：
4.7
通讯作者：
T. Williams
中科院分区：
文献类型：
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作者：
A. C. Black;D. Sandquist;J. R. West;J. Wamsley;T. Williams
摘要-毒扁豆碱胆碱能激动剂可增加许多神经组织中的环状GMP水平。由于大鼠的海马区接受隔区的胆碱能神经支配，我们决定测试大鼠海马区的环状GMP水平是否被M胆碱能激动剂Bethan ecol所增加。用不同浓度的苯二酚孵育大鼠海马区，结果表明，环化GMP水平的增加是浓度依赖的，500pb的苯二酚产生的最大值比对照组增加了490%。胆碱能受体激动剂阿托品可阻断胆碱能引起的兴奋性升高，并呈钙依赖性。结论：投射到大鼠海马区的细胞中至少有一部分形成M胆碱能突触，这种突触通过GMP依赖的循环机制发挥作用。
Abstract— Muscarinic cholinergic agonists increase cyclic GMP levels in a number of neural tissues. Since the rat hippocampus receives a cholinergic innervation from the septum, we decided to test whether cyclic GMP levels of the rat hippocampus are increased by bethanechol, a muscarinic cholinergic agonist. Incubation of rat hippocampi with varying concentrations of bethanechol showed that the increase in cyclic GMP levels is concentration‐dependent, 500 pwbethanechol producing a maximum increase of 490% over control values. The bethanechol‐evoked increases were blocked by the muscarinic antagonist atropine, and were calcium‐dependent. It is concluded that at least some of the cells projecting to the rat hippocampus form muscarinic cholinergic synapses which act via a cyclic GMP‐dependent mechanism.