Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer.
Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer.
复制标题
使用硅橡胶管进行局部激素治疗，以预防和治疗乳腺癌。
DOI：
10.1038/s41598-017-18436-1
复制
发表时间：
2018
影响因子：
4.6
通讯作者：
Munster,PamelaN
中科院分区：
文献类型：
--
作者：
Park,Jeenah;Thomas,Scott;Zhong,AllisonY;Wolfe,AlanR;Krings,Gregor;Terranova-Barberio,Manuela;Pawlowska,Nela;Benet,LeslieZ;Munster,PamelaN
Broad use of germline testing has identified an increasing number of women at risk for breast cancer with a need for effective chemoprevention. We report a novel method to selectively deliver various anti-estrogens at high drug levels to the breast tissue by implanting a device comprised of silastic tubing. Optimized tubing properties allow elution of otherwise poorly bioavailable anti-estrogens, such as fulvestrant, into mammary tissuein vitroandin vivowith levels sufficient to inhibit estrogen receptor activation and tumor cell proliferation. Implantable silastic tubing delivers fulvestrant selectively to mouse mammary fat tissue for one year with anti-tumor effects similar to those achieved with systemic fulvestrant exposure. Furthermore, local delivery of fulvestrant significantly decreases cell proliferation, as assessed by Ki67 expression, most effectively in tumor sections adjacent to tubing. This approach may thereby introduce a potential paradigm shift and offer a promising alternative to systemic therapy for prevention and early interception of breast cancer.
