Antimicrobial susceptibilities of clinical isolates of the anaerobic bacteria which can cause aspiration pneumonia
Antimicrobial susceptibilities of clinical isolates of the anaerobic bacteria which can cause aspiration pneumonia
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DOI：
10.1016/j.anaerobe.2019.04.002
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发表时间：
2019-06-01
期刊：
影响因子：
2.3
通讯作者：
Mikamo, Hiroshige
中科院分区：
文献类型：
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作者：
Fujita, Kiyoko;Takata, Iichiro;Mikamo, Hiroshige
吸入性肺炎是一种由吸入唾液或食物引起的肺部感染性疾病，与吞咽功能障碍有关。因此，主要的致病微生物是口腔或胃细菌。在这项研究中，我们评估了可引起吸入性肺炎的厌氧菌，梭杆菌属，大型Finegoldia magna，脆弱拟杆菌，消化链霉菌属，普氏菌属，米勒链球菌群对头孢曲松、头孢美唑、氟氧头孢、氨苄西林/舒巴坦和氨苄西林敏感。我们还测试了每种细菌菌株的β-内酰胺酶活性。梭杆菌属和Finegoldia magna对除氨苄青霉素外的所有测试的抗菌药物敏感，并且没有显示出β-内酰胺酶活性。米勒链球菌群、脆弱拟杆菌和消化链球菌属。与先前报告中记录的敏感性水平相比，显示对头孢美唑或氟氧头孢的敏感性降低。有一株厌氧消化链霉菌对氨苄西林/舒巴坦不敏感，但也显示无β-内酰胺酶活性，表明该菌株具有除产生β-内酰胺酶以外的耐药机制。普雷沃菌属的敏感性。对头孢曲松的敏感性也比以前的报告中记录的敏感性水平降低。此外。甚至在头孢曲松敏感菌株中也发现了β-内酰胺酶阳性菌株。患有吞咽功能障碍的老年人有反复发作吸入性肺炎的风险，反复使用抗生素会增加抗生素耐药性的风险。在本研究中，发现一些可引起吸入性肺炎的微生物的抗生素敏感性与先前报告中记录的敏感性水平相比有所降低。因此，建议监测这些细菌的抗菌药物敏感性模式，以防止耐药性的发展。(C)2019爱思唯尔有限公司发布
Aspiration pneumonia is an infectious disease of the lungs caused by inhalation of saliva or foods, associated with swallowing dysfunction. Therefore, the major causative organisms are oral or gastric bacteria. In this study, we evaluated the antimicrobial susceptibility patterns of the anaerobic bacteria which can cause aspiration pneumonia, Fusobacterium spp., Finegoldia magna, Bacteroides fragilis, Peptostreptococcus spp., Prevotella spp., and Streptococcus milleri group to ceftriaxone, cefmetazole, flomoxef, ampicillin/sulbactam, and ampicillin. We also tested the beta-lactamase activities of each of the bacterial strains. Fusobacterium spp. and Finegoldia magna were susceptible to all of the tested antimicrobial drugs, except ampicillin, and showed no beta-lactamase activity. The Streptococcus milleri group, Bacteroides fragilis, and Peptostreptococcus spp. showed decreased susceptibility to cefmetazole or flomoxef as compared to the susceptibility levels documented in a previous report. There was one strain of Peptostreptococcus anaerobius which was not susceptible to ampicillin/sulbactam, but also showed no beta-lactamase activity, suggesting that this strain harbored a mechanism of resistance other than the production of beta-lactamase. The susceptibility of Prevotella spp. to ceftriaxone was also decreased as compared to the susceptibility level documented in a previous report. Furthermore. beta-lactamase-positive strains were found even among ceftriaxone-susceptible strains. Elderly persons with swallowing dysfunction carry a risk of recurrent episodes of aspiration pneumonia and repeated use of antibiotics increases the risk of development of antibiotic resistance. In the present study, the antibiotic susceptibilities of some of organisms which can cause aspiration pneumonia were found to be decreased as compared to the susceptibility levels documented in a previous report. Therefore, surveillance of the antimicrobial susceptibility patterns of these bacteria is recommended to prevent the development of resistance. (C) 2019 Published by Elsevier Ltd.