Review of autoimmune (lupus-like) glomerulonephritis in murine models
Review of autoimmune (lupus-like) glomerulonephritis in murine models
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DOI：
10.1080/01913120600932677
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发表时间：
2006-09-01
影响因子：
1
通讯作者：
Bullard, Daniel C.
中科院分区：
文献类型：
--
作者：
Hicks, John;Bullard, Daniel C.
虽然小鼠自身免疫性(狼疮性)肾炎模型已经存在一段时间了，但直到最近才对免疫和炎症机制以及分子遗传学进行了广泛的研究。与小鼠和人类狼疮性肾炎相关的基因已经被发现，并提供了对这一疾病过程的洞察，并为分子靶向治疗提供了途径。小鼠肾炎的免疫调节为减轻这种疾病或阻止疾病进展的新疗法提供了洞察力。随着包括电子显微镜和分子遗传学在内的翻译研究方法在狼疮性肾炎发病机制方面的进展，许多“设计”的治疗方法已可用于临床和临床研究试验。本文综述了自身免疫性(狼疮性)肾炎小鼠模型、狼疮性肾炎相关候选基因、小鼠狼疮性肾炎相关的黏附分子、狼疮性肾炎的免疫调节机制以及免疫复合体肾炎的新的潜在治疗方法。
While murine models of autoimmune (lupus-like) glomerulonephritis have been available for sometime, it is only recently that immune and inflammatory mechanisms and molecular genetics have been extensively investigated. Genes involved in murine and human lupus nephritis have been discovered and provide insight into this disease process and provide avenues for molecular-targeted therapy. Immune modulation of murine nephritis has provided insight into novel therapy that may attenuate this disease or halt disease progression. With the advances in understanding the pathogenesis of lupus nephritis using translational research modalities, including electron microscopy, and molecular genetics, many "designer" therapies have become available for clinical use and for clinical investigational trials. This paper reviews autoimmune (lupus-like) glomerulonephritis in murine models, candidate genes involved in lupus nephritis, adhesion molecules implicated in murine lupus-like nephritis, immune modulation of murine lupus-like nephritis, and novel and potential therapy for immune complex glomerulonephritis.