Brain STAT5 signaling and behavioral control
Brain STAT5 signaling and behavioral control
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DOI：
10.1016/j.mce.2016.04.019
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发表时间：
2016-12-15
影响因子：
4.1
通讯作者：
Donato, J., Jr.
中科院分区：
文献类型：
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作者：
Furigo, Isadora C.;Ramos-Lobo, Angela M.;Donato, J., Jr.
多种生长因子和细胞因子通过STAT5 （signal transducer and activator of transcription 5）信号通路调控细胞增殖、分化和凋亡。尽管如此，这种转录因子对大脑功能的重要性仍然知之甚少。由于一些诱发stat5的激素，如催乳素和瘦素，在大脑中调节动机行为的表达，这条信号通路可能参与行为调节。因此，本综述的目的是总结和讨论有关中央STAT5信号在脑功能调节，特别是行为控制中的可能作用的现有数据。我们讨论了研究STAT5信号在调节母性和摄食行为中的重要性。此外，我们强调了可能受到STATS信号影响的其他行为。这一知识可能有助于理解动机行为是如何在细胞水平上受到调节的。2016爱思唯尔爱尔兰有限公司版权所有。
Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for brain functions is still poorly understood. Because some STAT5-inducing hormones, such as prolactin and leptin, act in the brain to regulate the expression of motivated behaviors, this signaling pathway is likely involved in behavioral modulation. Therefore, the objective of the present review was to summarize and discuss the available data regarding the possible role of central STAT5 signaling in the regulation of brain functions, especially on behavioral control. We discussed studies that investigated the importance of STAT5 signaling in the regulation of maternal and feeding behaviors. Additionally, we highlighted other behaviors that could be potentially affected by STATS signaling. This knowledge may help to understand how motivated behaviors are regulated at the cellular level. (C) 2016 Elsevier Ireland Ltd. All rights reserved.