Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?
Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?
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DOI：
10.1513/pats.200801-011aw
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Stripp, Barry R
中科院分区：
文献类型：
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作者：
Stripp, Barry R
在肺发育过程中发育中的肺内胚层的动态变化导致功能不同的上皮区室的建立，这些上皮区室在其细胞组成和有助于其在成年期维持的机制方面都不同。这篇集中的综述比较了缓慢和快速更新组织中细胞的层次组织，作为更好地理解调节肺上皮维持和修复的细胞和分子机制的基础。
Dynamic changes to the developing lung endoderm during the process of lung development result in the establishment of functionally distinct epithelial compartments that vary both in their cellular composition and mechanisms contributing to their maintenance in adulthood. This focused review compares the hierarchical organization of cells within slowly and rapidly renewing tissues as a basis to better understand cellular and molecular mechanisms regulating epithelial maintenance and repair in the lung.