Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers.
Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers.
复制标题
类风湿关节炎中环状RNA功能研究的现状及其作为诊断生物标志物的潜在作用
DOI：
10.2147/jir.s302846
复制
发表时间：
2021
影响因子：
4.5
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Xu Y;Chen F
摘要 环状RNA（circRNA）是一类新的内源性非编码RNA（ncRNA），具有高度稳定性并表现出组织特异性表达。越来越多的证据表明，circRNA在多种疾病的发生和发展中发挥着至关重要的作用。值得注意的是，circRNA是炎症和自身免疫调节中基因表达的重要表观遗传调节剂，与类风湿性关节炎（RA）的发病机制密切相关。 RA是最常见的系统性自身免疫性疾病之一，其特征是滑膜增生和炎症，以及软骨和骨质破坏。在此，我们重点关注巨噬细胞、滑膜组织、成纤维样滑膜细胞（FLS）和软骨组织中的circRNA在RA发病机制和进展中的作用，强调血液中的circRNA作为诊断生物标志物的潜力，旨在为该疾病的诊断和治疗提供新的见解。
Abstract Circular RNAs (circRNAs), a new class of endogenous non-coding RNAs (ncRNAs), are highly stable and exhibit tissue-specific expression. Accumulating evidence has indicated that circRNAs play crucial roles in the development and progression of multiple diseases. Notably, circRNAs, important epigenetic modulators of gene expression in inflammation and autoimmune regulation, have a close association with the pathogenesis of rheumatoid arthritis (RA). RA, one of the most common systemic autoimmune diseases, is characterized by synovial hyperplasia and inflammation, and cartilage and bone destruction. Here, we focus on the roles of circRNAs in macrophage, synovial tissues, fibroblast-like synoviocytes (FLSs), and cartilage tissues in pathogenesis and progression of RA, highlighting the potential of circRNAs in the blood as diagnostic biomarkers, and aiming at providing new insights into the diagnosis and therapy of this disease.