Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures: A preliminary report
Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures: A preliminary report
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DOI：
10.1016/j.jpor.2010.09.006
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Onozuka, Minoru
中科院分区：
文献类型：
--
作者：
Kimoto, Katsuhiko;Ono, Yumie;Onozuka, Minoru
目的：应用功能磁共振成像技术研究无牙颌患者从下颌全口义齿转向种植覆盖义齿时咀嚼口香糖时脑区活动的变化。方法：4例无牙颌患者，男3例，女1例，年龄~79岁。所有受试者都接受了一套新的上颌和下颌全口义齿(CD)，然后是上颌全口义齿和新的下颌种植支持的可拆卸覆盖义齿(IOD)。3-T功能磁共振成像扫描仪为每个受试者生成区域大脑活动的图像，显示在用CD和IOD咀嚼口香糖的过程中，轴向血氧水平依赖(BOLD)对比度的变化。结果：感兴趣区分析显示IOD治疗显著抑制了咀嚼诱导的前额皮质脑活动。IOD组大鼠咀嚼诱发的初级感觉运动皮质和小脑的脑活动有降低的趋势，但未达到显著水平。嚼CD口香糖和IOD口香糖对大鼠辅助运动区、丘脑和脑岛的脑活动无明显影响。使用统计参数映射的分组比较进一步显示，与CD相比，IOD咀嚼口香糖时额叶皮质内的神经活动显著降低(P<；0.05)。结论：尽管样本量有限，但这些结果表明老年无牙患者的咀嚼口香糖任务导致了下颌CD和IOD两种修复方法在额叶皮质内额极的神经活动差异。(C)2010年日本口腔修复学会。由爱尔兰爱思唯尔出版。版权所有。
Purpose: We used functional magnetic resonance imaging (fMRI) to investigate the change in brain regional activity during gum chewing when edentulous subjects switched from mandibular complete dentures to implant-supported removable overdentures.Methods: Four edentulous patients (3 males and 1 female, aged 64 to 79 years) participated in the study. All subjects received a set of new maxillary and mandibular complete dentures (CD), followed by a maxillary complete denture and a new mandibular implant-supported removable overdentures (IOD). A 3-T fMRI scanner produced images of the regional brain activity for each subject that showed changes in the blood-oxygenation- level-dependent (BOLD) contrast in the axial orientation during gum-chewing with CD and IOD.Results: Region-of-interest analysis showed that IOD treatment significantly suppressed chewing-induced brain activity in the prefrontal cortex. The chewing-induced brain activities in the primary sensorimotor cortex and cerebellum tended to decrease with IOD treatment, however they did not reach to significance level. There was no change in brain activity in the supplementary motor area, thalamus and insula between gum chewing with CD and IOD. Group comparison using statistical parametrical mapping further showed that, within the prefrontal cortex, the neural activity of the frontal pole significantly decreased during gum-chewing with IOD when compared to that with CD (P < 0.05).Conclusion: Despite the limitation of a small sample size, these results suggest that the gum-chewing task in elderly edentulous patients resulted in differential neural activity in the frontal pole within the prefrontal cortex between the 2 prosthodontic therapies-mandibular CD and IOD. (C) 2010 Japan Prosthodontic Society. Published by Elsevier Ireland. All rights reserved.