Mechanisms of cyanobactin biosynthesis.
Mechanisms of cyanobactin biosynthesis.
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DOI：
10.1016/j.cbpa.2016.08.029
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发表时间：
2016-12
影响因子：
7.8
通讯作者：
Naismith, James H.
中科院分区：
文献类型：
--
作者：
Czekster, Clarissa Melo;Ge, Ying;Naismith, James H.
蓝藻菌素是一种不同的天然产物，起源于核糖体上的短肽。氨基酸在一系列由多种酶催化的转化中被修饰。髌骨酰胺途径是研究得最充分和表征的例子。本文综述了肽键、大环肽、杂环半胱氨酸（以及苏氨酸和丝氨酸）残基、氧化五元杂环和连接戊烯基的酶的结构和机制。一些酶是通过新的机制运作的，这是有趣的，此外，酶从催化中解耦识别。这些因素之间通常紧密的关系阻碍了生物技术的发展。随着体内和体外方法的进展，蓝藻蛋白途径可能特别适合开发。
Cyanobactins are a diverse collection of natural products that originate from short peptides made on a ribosome. The amino acids are modified in a series of transformations catalyzed by multiple enzymes. The patellamide pathway is the most well studied and characterized example. Here we review the structures and mechanisms of the enzymes that cleave peptide bonds, macrocyclise peptides, heterocyclise cysteine (as well as threonine and serine) residues, oxidize five-membered heterocycles and attach prenyl groups. Some enzymes operate by novel mechanisms which is of interest and in addition the enzymes uncouple recognition from catalysis. The normally tight relationship between these factors hinders biotechnology. The cyanobactin pathway may be particularly suitable for exploitation with progress in vivo and in vitro approaches observed.
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通讯作者：
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通讯作者：
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