Computer Assisted Analysis of MR-Mammography Reveals Association Between Contrast Enhancement and Occurrence of Distant Metastasis
Computer Assisted Analysis of MR-Mammography Reveals Association Between Contrast Enhancement and Occurrence of Distant Metastasis
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DOI：
10.7785/tcrt.2012.500266
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发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Dietzel, Matthias
中科院分区：
文献类型：
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作者：
Baltzer, Pascal A. T.;Zoubi, Ramy;Dietzel, Matthias
动态对比增强磁共振成像（DCE-MRI）能够以高灵敏度检测乳腺癌。此外，该方法提供了关于组织组成和血管形成的功能信息。本研究旨在通过计算机辅助解释动态增强数据，确定DCE-MRI预测乳腺癌患者远处转移的潜力。为此，根据国际建议，59例新诊断的浸润性乳腺癌患者接受了1.5特斯拉的治疗前DCE-MRI。记录所有患者的随访时间和远处转移的发生率。对于DCE-MRI分析，使用专用软件（Brevis，Siemens Healthcare，埃尔兰根，德国）。它允许半自动识别分析的病变中最可疑的曲线。评估的增强参数为“初始增强”、“洗脱”、“峰值增强”和“达到峰值增强的时间”。采用考克斯比例风险回归（CPHR）分析这些参数对异时远处转移概率的影响。中位随访时间为52.0个月。6例患者在乳腺癌诊断后11至35个月发生远处转移。在CPHR中，洗脱期是发生远处转移的独立预测因子（P = 0.0134）。我们的初步数据表明，计算机测量的增强参数在DCE-MRI和发生远处转移的量化洗脱之间的关联。
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is able to detect breast cancer with high sensitivity. Furthermore, this method provides functional information on tissue composition and vascularization. This study aims to identify the potential of DCE-MRI to predict distant metastasis in breast cancer patients using computer assisted interpretation of dynamic enhancement data. For this purpose, 59 consecutive patients with newly diagnosed invasive breast cancer received pretherapeutic DCE-MRI at 1.5 Tesla according to international recommendations. In all patients, follow up interval and occurrence of distant metastasis was documented. For DCE-MRI analysis dedicated software was used (Brevis, Siemens Healthcare, Erlangen, Germany). It allows semiautomatic identification of the most suspect curve in a lesion analyzed. Enhancement parameters assessed were "Initial Enhancement", "Washout", "Peak-Enhancement", and "Time to Peak Enhancement". Cox proportional hazards regression (CPHR) was used to analyze the effect of these parameters on the probability of metachronous distant metastasis. Median follow up period was 52.0 months. 6 patients developed distant metastases between 11 and 35 months after breast cancer diagnosis. In CPHR, Washout could be identified as significant and independent predictor for occurrence of distant metastasis (P = 0.0134). Our initial data demonstrate an association between computer measured enhancement parameters in DCE-MRI and occurrence of distant metastasis by quantification of Washout.