The immune response to airway mycosis.
The immune response to airway mycosis.
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DOI：
10.1016/j.mib.2021.04.009
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发表时间：
2021-08
影响因子：
5.4
通讯作者：
Corry DB
中科院分区：
文献类型：
--
作者：
Li E;Rodriguez A;Luong AU;Allen D;Knight JM;Kheradmand F;Corry DB
过敏性气道疾病慢性鼻窦炎 (CRS)、过敏性真菌性鼻窦炎 (AFRS)、哮喘、过敏性支气管肺真菌病/曲霉病 (ABPM/A) 和囊性纤维化 (CF) 具有共同的免疫学特征，以 T H 2 和 TH 17 细胞为主的免疫反应、IgE 抗体的产生以及包括嗜酸性粒细胞和其他先天免疫效应细胞。长期以来，这些疾病的严重形式一直被认为与对环境真菌的过敏反应有关。然而，环境真菌越来越多地在这些疾病的病因学中发挥着更重要的作用，气道真菌病（一种非侵入性气道真菌感染）被认为是至少严重的过敏性气道疾病的重要驱动因素。在这篇综述中，我们考虑了最近在理解驱动气道真菌病相关疾病的免疫机制、基于免疫的诊断策略的改进以及针对关键免疫途径的治疗方法方面取得的进展。
The allergic airway diseases chronic rhinosinusitis (CRS), allergic fungal rhinosinusitis (AFRS), asthma, allergic bronchopulmonary mycosis/aspergillosis (ABPM/A), and cystic fibrosis (CF) share a common immunological signature marked by T H 2 and TH 17 cell predominant immune responses, the production of IgE antibody, and atypical inflammatory cell infiltrate that includes eosinophils and other innate immune effector cells. Severe forms of these disorders have long been recognized as being related to hypersensitivity reactions to environmental fungi. Increasingly however,environmental fungi are assuming a more primary role in the etiology of these disorders, with airway mycosis, a type of non-invasive airway fungal infection,recognized as an essential driving factor in at least severe subsets of allergic airway diseases. In this review, we consider recent progress made in understanding the immune mechanisms that drive airway mycosis-related diseases, improvements in immune-based diagnostic strategies, and therapeutic approaches that target key immune pathways.
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影响因子：
14.2
作者：
Porter, Paul C.;Lim, Dae Jun;Maskatia, Zahida Khan;Mak, Garbo;Tsai, Chu-Lin;Citardi, Martin J.;Fakhri, Samer;Shaw, Joanne L.;Fothergil, Annette;Kheradmand, Farrah;Corry, David B.;Luong, Amber
通讯作者：
Luong, Amber
影响因子：
4.8
作者：
Knight, J. Morgan;Mandal, Pijus;McMurray, John S.
通讯作者：
McMurray, John S.
影响因子：
2.6
作者：
Dietz, Caroline J.;Sun, Hua;Luong, Amber U.
通讯作者：
Luong, Amber U.
DOI：
10.1177/1179550618792254
发表时间：
2018
期刊：
Clinical medicine insights. Ear, nose and throat
影响因子：
--
作者：
Jiang RS;Huang WC;Liang KL
通讯作者：
Liang KL
影响因子：
1.4
作者：
Park, Hyun Joo;Seoh, Ju-Young;Lee, Seung-Sin
通讯作者：
Lee, Seung-Sin