Canine muscle blood flow during fractionated hyperthermia.
Canine muscle blood flow during fractionated hyperthermia.
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分段热疗期间的犬肌肉血流。
DOI：
10.3109/02656738709140406
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
A. Milligan
中科院分区：
文献类型：
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作者：
A. Milligan
血流是获得肿瘤和正常组织均匀热分布的重要参数。本研究观察了30只犬分次热疗对肌肉血流量的影响。将这些动物分为5组，每组接受0（对照）、1、2、3或4次热疗，间隔72 h。每只动物在45 ℃下处理40分钟。在加热10、20、30或40分钟时，用四种不同的放射性微球测量血流量。在第一次治疗期间，血流量从对照组的7.5 +/- 1.1 ml min-1/100 g组织增加到加热20 min时的39.6 +/- 5.8 ml min-1/100 g组织。在接下来的20分钟内，血流量下降至24.4 +/- 4.8 ml min-1/100 g组织。对所有热疗治疗重复这种模式，并且在加热20和30分钟之间观察到所有组的峰值血流量。峰值血流量分别达到20.0，16.5和11.0 ml min-1/100 g组织的动物与2，3，或4热疗分数，分别。这些数据表明，正常组织中的峰值血流量随着热疗分数的增加而降低。血流对热疗的反应从一部分到另一部分发生变化，这些变化的动力学描述对于理解正常组织对热的反应是重要的。
Blood flow is an important parameter for obtaining uniform thermal distributions in tumour and normal tissue. This study investigated the effect of fractionated hyperthermia on muscle blood flow in 30 dogs treated interstitially. These animals were divided into five groups, each group receiving either 0 (control), 1, 2, 3, or 4 hyperthermia fractions separated by 72 h. Each animal was treated for 40 min at 45 degrees C. Blood flow was measured with four different radioactive microspheres at either 10, 20, 30, or 40 min of heating. During the first treatment, blood flow increased from control of 7.5 +/- 1.1 ml min-1/100 g of tissue to 39.6 +/- 5.8 ml min-1/100 g of tissue at 20 min of heating. Blood flow decreased over the next 20 min to 24.4 +/- 4.8 ml min-1/100 g of tissue. This pattern was repeated for all hyperthermia treatments and peak blood flows were observed for all groups between 20 and 30 min of heating. Peak blood flows reached 20.0, 16.5 and 11.0 ml min-1/100 g of tissue for animals treated with 2, 3, or 4 hyperthermia fractions, respectively. These data suggest that peak blood flow in normal tissue decreased with increasing numbers of hyperthermia fractions. Blood flow response to hyperthermia changes from fraction to fraction and description of the kinetics of these changes is important for understanding the response of normal tissue to heat.