Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo
Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo
复制标题
DOI：
10.1073/pnas.93.18.9921
复制
发表时间：
1996-09-03
影响因子：
11.1
通讯作者：
Bragin, A
中科院分区：
文献类型：
--
作者：
Buzsaki, G;Penttonen, M;Bragin, A
在麻醉的大鼠中，通过同时记录细胞外电位和细胞内电位，以及在自由活动的动物中，通过同时记录细胞外电位和树突电位，研究了钠峰电位从索马侵入海马锥体细胞树突的情况。在复杂的尖峰模式，记录在不动或睡眠的动物，树突入侵连续尖峰大幅衰减。复杂的棘波爆发发生与CA 3-CA 1锥体细胞的群体放电（尖波场事件）。突触抑制降低了树突钠峰的幅度，并阻止了钙峰的发生。这些结果表明：（i）电压依赖性的钙离子流入树突的抑制性神经元的控制下，（ii）突触去极化和激活电压依赖性的钙电导的时间重合的反向传播尖峰在尖波爆发可能是至关重要的突触可塑性在完整的海马。
The invasion of sodium spikes from the soma into dendrites was studied in hippocampal pyramidal cells by simultaneous extracellular and intracellular recordings in anesthetized rats and by simultaneous extracellular recordings of the somatic and dendritic potentials in freely behaving animals. During complex-spike patterns, recorded in the immobile or sleeping animal, dendritic invasion of successive spikes was substantially attenuated. Complex spike bursts occurred in association with population discharge of CA3-CA1 pyramidal cells (sharp wave field events). Synaptic inhibition reduced the amplitude of sodium spikes in the dendrites and prevented the occurrence of calcium spikes. These findings indicate that (i) the voltage-dependent calcium influx into the dendrites is under the control of inhibitory neurons and (ii) the temporal coincidence of synaptic depolarization and activation of voltage-dependent calcium conductances by the backpropagating spikes during sharp wave bursts may be critical for synaptic plasticity in the intact hippocampus.