CURRENT TOPIC - HUMAN PLACENTA - A DIRECT TARGET FOR COCAINE ACTION
CURRENT TOPIC - HUMAN PLACENTA - A DIRECT TARGET FOR COCAINE ACTION
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DOI：
10.1016/s0143-4004(05)80181-x
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发表时间：
1994-12-01
期刊：
影响因子：
3.8
通讯作者：
LEIBACH, FH
中科院分区：
文献类型：
--
作者：
GANAPATHY, V;LEIBACH, FH
众所周知，怀孕期间使用可卡因对母亲和胎儿有有害影响。目前可用的模型描述这些影响的发病机制集中在可卡因靶系统的参与，主要是去甲肾上腺素转运蛋白，在母亲和胎儿。位于母亲和胎儿之间的胎盘在妊娠期间可卡因引起的并发症的整个过程中只被认为是“沉默的观察者”。然而，最近的研究表明，胎盘表达几种可卡因靶蛋白，如去甲肾上腺素转运蛋白、5-羟色胺转运蛋白和σ受体。这些蛋白质的功能显着受损，在可卡因的浓度已知存在于可卡因用户的血浆中的可卡因的存在。这些研究清楚地表明，胎盘本身是可卡因作用的直接靶点，可卡因与胎盘中靶蛋白的相互作用在母亲及其发育中的胎儿中可卡因诱导的并发症的发病机制中起着重要作用。
Use of cocaine during pregnancy is known to have harmful effects on the mother and her fetus. Currently available models describing the pathogenesis of these effects focus on the involvement of cocaine target systems, primarily the noradrenaline transporter, in the mother and the fetus. The placenta which lies between the mother and the fetus is considered only as a 'silent observer' in the whole process of cocaine-induced complications during pregnancy. Recent studies have, however, shown that the placenta expresses several cocaine target proteins such as the noradrenaline transporter, the serotonin transporter, and the sigma receptor. The functions of these proteins are significantly impaired in the presence of cocaine at concentrations known to exist in the plasma of cocaine users. These studies clearly show that the placenta itself is a direct target for cocaine action and that interaction of cocaine with its target proteins in the placenta plays an important role in the pathogenesis of cocaine-induced complications in the mother and her developing fetus.