An analysis of cancer prevention by selenium
An analysis of cancer prevention by selenium
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DOI：
10.1002/biof.5520140120
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发表时间：
2001-01-01
期刊：
影响因子：
6
通讯作者：
Turnbull, BW
中科院分区：
文献类型：
--
作者：
Combs, GF;Clark, LC;Turnbull, BW
硒(Se)的营养功能被认为是由于许多含Se的蛋白质所致。然而，目前还不清楚这些是否在硒的抗肿瘤作用中发挥作用，其中大多数已被证明对硒的暴露比硒蛋白表达所需的作用更大。事实上，某些硒代谢物的其他抗肿瘤机制已经被证明。癌症营养预防试验发现，在治疗前血浆硒浓度低于约120 ng/ml(1.5nmoles/ml)的受试者中，补充硒(200杯/天，作为富硒酵母)与显著降低癌症风险有关，这一水平似乎需要摄入约1.5杯/公斤体重/天的食物硒。然而，推测的抗癌硒代谢物(S)作为癌症预防的补充靶点，应该比血浆总硒更有意义。这些可能是血浆中非蛋白结合组分的硒，占血浆总硒的2-4%。
The nutritional functions of selenium (Se) are recognized as being due to a number of Se-containing proteins. It is not clear, however, whether any of these function in the anti-tumorigenic effects of Se most of which have been demonstrated for Se exposures greater than those required for selenoprotein expression. Indeed, other anti-tumorigenic mechanisms have been demonstrated for certain Se-metabolites. The Nutritional Prevention of Cancer Trial found supplemental Se (200 mug/day, as Se-enriched yeast) to be associated with significant reductions in cancer risks in subjects with pre-treatment plasma Se concentrations below ca. 120 ng/ml (1.5 nmoles/ml), which level would appear to require food-Se intakes of ca. 1.5 mug/kg body weight/day. However, the putative anti-carcinogenic Se-metabolite(s) should be more relevant than total plasma Se as a supplementation target for cancer prevention. These may be components of the non-protein-bound fraction of Se in plasma, which constitutes 2-4% of total plasma Se.