Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?
Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?
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DOI：
10.2991/efood.k.200211.001
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Stoner G
中科院分区：
文献类型：
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作者：
Wang LS;Echeveste CE;Yu J;Huang YW;Lechner J;Mei L;Sanvanson P;Yearsley M;Wang CK;Stoner G
世界上超过50%的人口感染了幽门螺杆菌。H.幽门螺杆菌是胃溃疡和胃癌的主要致病因素。H.使用抗生素单独或与质子泵抑制剂一起根除幽门是降低胃癌发病率的主要策略。尽管根除治疗有效，但也存在明显的不良反应，更重要的是，会出现抗生素耐药性，这是一个重大的治疗挑战。多种天然产物已被证明可以抑制H。幽门螺杆菌的体外和动物模型系统。然而，只有少数天然产品在人体临床试验中进行了评估。本综述的重点是总结已发表的人体临床试验的结果，以评估天然产物减少或消除H。幽门感染目前的证据表明，这些产品似乎有很大的潜力被开发为根除H。pylori，希望既有抗生素敏感菌株又有抗生素耐药菌株。经常食用当地生产的食品来控制H。幽门螺杆菌感染在世界各地的不同国家可能是一个可行的长期解决方案，以打击这种世界范围内流行的病原体。
More than 50% of the world’s population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of gastric cancer. Although eradication therapy is effective, there are significant adverse effects and more importantly, resistance to antibiotics occurs, which represents a major therapeutic challenge. Multiple natural products have been shown to suppress H. pylori both in vitro and in animal model systems. However, only a handful of natural products have been evaluated in human clinical trials. The focus of this review is to summarize the results of published human clinical trials to assess the ability of natural products to reduce or eliminate H. pylori infections. Current evidence suggests that these products appear to have great potential to be developed as pharmaceutical candidates for eradication of H. pylori, hopefully both antibiotic-sensitive and antibiotic-resistant strains. Frequent consumption of locally produced foodstuff for controlling H. pylori infection in different countries around the world may well be a feasible long-term solution to fight against this worldwide prevalent pathogen.