The change of prefrontal QEEG theta cordance as a predictor of response to bupropion treatment in patients who had failed to respond to previous antidepressant treatments
The change of prefrontal QEEG theta cordance as a predictor of response to bupropion treatment in patients who had failed to respond to previous antidepressant treatments
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DOI：
10.1016/j.euroneuro.2010.03.007
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发表时间：
2010-07-01
影响因子：
5.6
通讯作者：
Hoeschl, Cyril
中科院分区：
文献类型：
--
作者：
Bares, Martin;Brunovsky, Martin;Hoeschl, Cyril
本研究的目的是检查是否减少θ前额定量脑电图（QEEG）cordance后一周的安非他酮管理是一个预测的反应，4周的治疗患者没有响应以前的抗抑郁药治疗。方法：对18例住院患者进行基线及1周后的脑电图监测。在3个额叶电极（Fp1，Fp2，Fz）上计算QEEG一致性。对治疗的反应定义为MADRS评分降低>= 50%。结果如下：治疗第一周后，11名应答者中的9名和7名无应答者中的1名显示前额叶cordance值降低（p=0.01）。一致性降低预测治疗反应的阳性和阴性预测值分别为0.9和0.75。结论：与其他抗抑郁药类似，减少前额QEEG一致性可能有助于预测安非他酮治疗的急性结局。(C)2010 Elsevier B.V.和ECNP。All rights reserved.
The aim of the study was to examine whether the reduction of theta prefrontal quantitative EEG (QEEG) cordance after one week of bupropion administration is a predictor of response to a 4-week treatment in patients that had failed to respond to previous antidepressant treatments. Method: EEG data of 18 inpatients were monitored at baseline and after one week. QEEG cordance was computed at 3 frontal electrodes (Fp1, Fp2, Fz). Response to treatment was defined as a >= 50% reduction of MADRS score. Results: Nine of the eleven responders and one of the seven non-responders showed decreased prefrontal cordance value after the first week of treatment (p=0.01). Positive and negative predictive values of cordance reduction for the prediction of response to the treatment were 0.9 and 0.75, respectively. Conclusion: Similar to other antidepressants, the reduction of prefrontal QEEG cordance might be helpful in the prediction of the acute outcome of bupropion treatment. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.