Recent advances in the understanding of acute kidney injury.
Recent advances in the understanding of acute kidney injury.
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DOI：
10.12703/p6-83
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Westenfelder C
中科院分区：
文献类型：
--
作者：
Tögel F;Westenfelder C
急性肾损伤（AKI）是一种常见的临床病症，与高发病率、高死亡率以及临床成本相关。其病理生理学是多方面的，涉及炎症、肾小管损伤和血管损伤。近期发现的组成部分包括坏死性凋亡（一种特殊的细胞死亡形式）和自噬。大部分病理生理学知识是从动物模型中获得的，但这些并不能直接反映临床实际情况。肾小管细胞具有显著的再生能力，并且干细胞/祖细胞的作用也在探讨之中。急性肾损伤常常与慢性肾脏病相关，其影响广泛。
Acute kidney injury (AKI) is a common clinical entity associated with high morbidity and mortality and clinical costs. The pathophysiology is multifaceted and involves inflammation, tubular injury, and vascular damage. Recently identified components include necroptosis, a special form of cell death, and autophagy. Most of the pathophysiological knowledge is obtained from animal models but these do not directly reflect the reality of the clinical situation. Tubular cells have a remarkable capacity to regenerate, and the role of stem/progenitor cells is discussed. Acute kidney injury is frequently associated with chronic kidney disease, and the implications are widespread.