The Argus™ II retinal prosthesis: Factors affecting patient selection for implantation
The Argus™ II retinal prosthesis: Factors affecting patient selection for implantation
复制标题
DOI：
10.1016/j.preteyeres.2013.01.002
复制
发表时间：
2013-09-01
影响因子：
17.8
通讯作者：
Behrend, Matthew R.
中科院分区：
文献类型：
--
作者：
Ahuja, Ashish Kishore;Behrend, Matthew R.
Argus II视网膜前膜假体的开发旨在为因外部视网膜退行性疾病而失明的受试者提供部分视力恢复。迄今为止，作为全球临床可行性研究（clinicaltrials.gov ID：NCT 00407602）的一部分，该器械已植入多名重度视网膜色素变性受试者。Argus II预期用于部分恢复功能性视力。大多数受试者在评估方向82移动性，空间运动定位和辨别运动刺激的运动方向的能力的任务中表现出改善。大约三分之一的受试者在植入后视力有了可测量的改善。一些受试者识别单词的准确率很高，这一结果也被领先的视网膜下植入组报道。知觉阈值与电极-视网膜距离、电极-中心凹距离和光敏感度相关，无论是作为单变量还是在双变量线性回归中。这三个变量合在一起可用于告知患者选择并开发用于拟合更高电极计数系统的算法。未来几代Argus植入物的视力可能不会达到理论极限，直到阵列容纳超过数百个电极。然而，初步的安全性和有效性数据支持开发更高分辨率的系统，从植入物设计和手术角度来看，该系统以黄斑放置为目标。(c)2013爱思唯尔有限公司保留所有权利。
The Argus II epiretinal prosthesis has been developed to provide partial restoration of vision to subjects blinded from outer retinal degenerative disease. To date, the device has been implanted in multiple subjects with profound retinitis pigmentosa as part of a worldwide clinical feasibility study (clinicaltrials.gov ID: NCT00407602). The Argus II is intended to provide partial restoration of functional vision. Most subjects showed an improvement in tasks assessing orientation 82 mobility, spatial-motor localization, and ability of discerning the direction of motion of moving stimuli. Roughly one third of subjects experienced measurable improvement in visual acuity with the implant. Some subjects identified words with high accuracy, a result that has also been reported by the leading subretinal implant group. Perceptual threshold was correlated with electrode-retina distance, electrode-fovea distance, and light sensitivity, either as single variables or in bivariate linear regression. Taken together these three variables may be used to inform patient selection and develop algorithms for the fitting of higher-electrode count systems. Visual acuity for future generations of the Argus implant may not hit theoretical limitations until arrays hold an excess of several hundreds of electrodes. Nevertheless, preliminary safety and efficacy data are supportive of the development of higher-resolution systems that target macular placement from implant design and surgical perspectives. (c) 2013 Elsevier Ltd. All rights reserved.